Review of NICE's recommendations, 1999-2005

NICE ID

DISEASE/CONDITION

Health Technology

‘Yes, can or should be used’

Yes,

Minor

Restrictions

Yes,

Major restrictions

No, due to lack of evidence or poor cost effectiveness

1

Wisdom teeth

Prophylactic removal

X

2

Primary total hip replacement

Hip prostheses

x

3

Ovarian cancer, recurrent (resistant)

Paclitaxel

x

4

Ischaemic heart disease

Coronary artery stents

x

5

Cervical smear tests

Liquid based cytology

X

6

Breast cancer

Paclitaxel/docetaxel

X

7

Dyspepsia

Proton pump inhibitors

x

8

Hearing

Hearing aid technology

X

9

Type 2 diabetes mellitus

Rosiglitazone

X

10

Asthma, under 5s

Inhaler systems

x

11

Arrhythmias

Implantable cardioverter defibrillators

x

12

Acute coronary syndromes: medical management

Glycoprotein Iib/iiia inhibitors

x

12

Acute coronary syndromes – adjunct to percutaneous coronary intervention (PCI)

Glycoprotein Iib/iiia inhibitors

x

13

Attention deficit hyperactivity disorder in childhood

Methylphenidate

x

14

Hepatitis C

Ribavarin and interferon alpha combination therapy

x

15

Influenza

Zanamivir, at-risk adults

x

15

Influenza

Zanamivir, healthy adults

X

16

Knee joint defects

Autologues cartilage transplantation

X

17

Colorectal cancer

Laparoscopic surgery

X

18

Inguinal hernia, recurrent and bilateral

Laparoscopic surgery

x

18

Inguinal hernia, primary

Laparoscopic surgery

X

19

Alzheimer's disease

Donepezil/rivastigmine/ galantamine

x

20

Motor neurone disease

Riluzole

X

21

Type 2 diabetes melitus

Pioglitazone

X

22

Obesity

Orlistat

x

23

Brain cancer, recurrent

Temozolomide

x

24

Wound care

Debriding agents

X

25

Pancreatic cancer

Gemcitabine

x

26

Lung cancer, non-small cell

First line (paclitaxel, gemcitabine, vinorelbine)

X

26

Lung cancer, non-small cell

Docetaxel, 2^nd line

x

27

Rheumatoid arthritis/osteoarthritis

Meloxicam, etodolac, rofecoxib, celecoxib

x

28

Ovarian cancer, advanced

Topotecan

X

29

Lymphocytic leukaemia, B-cell chronic

Fludarabine

X

30

Breast cancer, advanced

Docetaxel, 1^st line

x

30

Breast cancer, advanced

Paclitaxel, docetaxel, 2^nd line

x

31

Obesity

Sibutramine

x

32

Multiple sclerosis

Beta interferon, glatimer

X

33

Colorectal cancer, advanced

Irinotecan, 2^nd line monotherapy

X

33

Colorectal cancer, advanced

Irinotecan, 1^st line use in combination therapy

X

33

Colorectal cancer, advanced

Oxaliplatin, 1st line

x

33

Colorectal cancer, advanced

Raltitrexed

X

34

Breast cancer, advanced

Trastuzumab

X

35

Juvenile idiopathic arthritis

Etanercept

X

36

Rheumatoid arthritis

Infliximab, etanercept

X

37

Lymphoma, follicular non-Hodgkin's

Rituximab, 3^rd or subsequent line

x

38

Asthma, older children

Inhaler devices

x

39

Smoking cessation

Bupropion

X

39

Smoking cessation

Nicotine replacement therapy

X

40

Crohn's disease- severe active

Infliximab

X

Crohn's disease- fistulising

Infliximab

X

41

Pregnancy, rhesus negative women

Routine anti-D prophylaxis

X

42

Growth hormone deficiency - children,

Somatropin

X

43

Schizophrenia

Amisulpride, Olanzapine, quetiapine, risperidone, zotepine

x

43

Schizophrenia

Clozapine

x

44

Hip resurfacing

Metal on metal

x

45

Ovarian cancer, advanced

Pegylated liposomal doxorubicin hydrochloride (PLDH)

X

46

Obesity

Surgical treatments

x

47

Acute coronary syndromes- medical management

Glycoprotein iib/iiia inhibitors

x

47

Acute coronary syndromes- adjunct to PCI

Glycoprotein iib/iiia inhibitors

X

48

Renal (ESRD)

Home haemodialysis

X

49

Central venous catheters

2-D imaging ultrasound guidance device

X

49

Central venous catheters

Audio-guided Doppler ultrasound guidance device

X

50

Leukaemia, chronic myeloid--chronic phase, 2^nd line therapy

Imatinib

X

50

Leukaemia, chronic myeloid--accelerated phase

Imatinib

X

50

Leukaemia, chronic myeloid--blast phase

Imatinib

X

51

Depression and anxiety

Computerised cognitive behaviour therapy

X

52

Acute myocardial infarction, early thrombolysis

Alteplase, reteplase, tenecteplase. Streptokinase

X

53

Diabetes, type 2

Insulin glargine,

X

53

Diabetes, type 1

Insulin glargine

X

54

Breast cancer, advanced- 1^st line

Vinorelbine

x

54

Breast cancer, advanced – 2^nd line

Vinorelbine

X

55

Ovarian cancer

Paclitaxel

X

56

Stress incontinence

Tension-free vaginal tape (Gynecare TVT)

x

57

Diabetes

Continuos subcutaneous insulin infusion

x

58

Influenza

Zanamivir, oseltamivir in at risk adults

X

58

Influenza

Zanamivir, Oseltamivir in healthy adults

X

58

Influenza

Amantadine: at risk or healthy adults

X

59

Severe depressive illness, catatonia, prolonged or severe manic episode

Electroconvulsive therapy (ECT)

x

59

Schizophrenia: schizophrenia

Electroconvulsive therapy (ECT)

X

60

Diabetes

Patient education models

x

61

Colorectal cancer, metastatic

Capecitabine, tegafur with uracil

x

62

Breast cancer, advanced or metastatic

Capecitabine, plus docetaxel

X

62

Breast cancer, advanced or metastatic

Capecitabine monotherapy, 2^nd line

X

63

Diabetes, type 2

Combination therapy with glitazones

x

64

Growth hormone deficiency: adults

Somatropin

X

65

Agressive inon-Hodgkin’s lymphoma

Rituximab

X

66

Bipolar I disorder, acute mania

Valproate semisodium, olanzapine

X

67

Influenza, seasonal prophylaxis,

Oseltamivir

X

67

Influenza, post-exposure

Oseltamivir

x

67

Influenza, seasonal prophylaxis

Amantadine

X

67

Influenza, post-exposure

Amantadine

X

68

Age-related macular degeneration, classic with no occult CNV

Photodynamic therapy

x

68

Age-related macular degeneration, predominantly classic CNV

Photodynamic therapy

X

69

Cervical screening

Liquid-based cytology

x

70

Chronic myeloid leukaemia (chronic, accelerate and blast)

Imatinib

x

71

Coronary heart disease (angina or MI)

Bare-metal stent

x

71

Coronary heart disease (angina or MI)

Drug eluting stent

x

72

Rheumatoid arthritis

Anakinra

X

73

Coronary artery disease

MPS with SPECT,

X

74

Trauma

Pre-hospital fluid replacement therapy

x

75

Chronic hepatitis C

Peginterferon alfa and ribavirin – combination therapy

X

75

Chronic hepatitis C

Peginterferon alfa - monotherpay

X

76

Epilepsy in adults

Newer drugs

X

77

Insomnia

Zaleplon, zolpidem, zopiclone

X

78

Heavy menstrual bleeding

Fluid filled balloon, microwave ablation

X

79

Epilepsy - children

Newer drugs

X

80

Acute coronary syndromes (NSTEMI)

Clodipogrel

X

81

Atopic eczema

Topical corticosteroids

X

82

Atopic eczema

Tacrolimus

X

82

Atopic eczema

Pimecrolimus

X

83

Inguinal hernia repair

Laparoscopic surgery

X

84

Severe sepsis

Drotrecogin

X

85

Immunosuppressive therapy post renal transplantation

Induction therapy (basiliximab, daclizumab)

X

85

Immunosuppressive therapy post renal transplantation

Tacrolimus in triple therapy

X

85

Immunosuppressive therapy post renal transplantation

MMF in triple therapy

X

85

Immunosuppressive therapy post renal transplantation

Sirolimus in triple therapy

X

86

Gastro intestinal stromal tumours (GIST)

Imatinib

X