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Serotonin selective reuptake inhibitors are associated with increased risk of suicide in older people

BMJ 2006; 332 doi: http://dx.doi.org/10.1136/bmj.332.7551.0-e (Published 18 May 2006) Cite this as: BMJ 2006;332:0-e

Research question Is there a link between suicide and selective serotonin reuptake inhibitors (SSRIs) in older people?

Answer Yes, but only during the first month of treatment.

Why did the authors do the study? SSRIs have been linked to suicidal thoughts in adolescents. These authors wanted to explore any link in older adults because they are often prescribed antidepressants and may be particularly vulnerable to suicide.

What did they do? The authors did a large case-control study starting with all adults aged at least 66 who had committed suicide in Ontario between 1992 and 2000. They closely matched each of …

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