Letter

Case reports of suspected adverse drug reactions: Case reports were dismissed too quickly

BMJ 2006; 332 doi: 10.1136/bmj.332.7539.488 (Published 23 February 2006)
Cite this as: BMJ 2006;332:488.1

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  1. Jan P Vandenbroucke, professor of clinical epidemiology (J.P.Vandenbroucke@lumc.nl)
  1. Leiden University Medical Center, 2300 RC Leiden, Netherlands

    EDITOR—The main difference between the replications by Loke et al of Venning's studies from the 1980s and the original is the evidence that is accepted as further follow-up.1 Loke et al mention that 56 of 63 case reports on adverse reactions were cited at least once but accept only nine instances as valid follow-up: attempts at proof of mechanisms or controlled studies. However, unexpected adverse effects are …

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