More evidence that hormone replacement therapy causes incontinence in postmenopausal womenBMJ 2006; 332 doi: https://doi.org/10.1136/bmj.332.7538.0-e (Published 16 February 2006) Cite this as: BMJ 2006;332:0-e
Research question Does combined hormone replacement therapy increase the risk of incontinence in postmenopausal women with heart disease?
Answer Yes. In a large clinical trial, women taking hormone therapy were more likely to develop incontinence than women taking a placebo.
Why did the authors do the study? Evidence is mounting that hormone replacement therapy increases the risk of urinary incontinence in postmenopausal women. A re-analysis of one large randomised controlled trial, the women's health initiative, is already persuasive. These authors wanted to confirm the link using data from a second large trial, the heart and estrogen-progestin replacement study (HERS), which compared hormone replacement therapy …