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BMJ 2005; 331 doi: https://doi.org/10.1136/bmj.331.7529.1363 (Published 08 December 2005) Cite this as: BMJ 2005;331:1363
  1. Harvey Marcovitch, BMJ syndication editor (h.marcovitch@btinternet.com)

    Anti-epileptics can be withdrawn safely in pseudoseizures

    Anticonvulsant drugs can safely be stopped in patients with pseudoseizures (non-epileptic seizures) with little risk of provoking fits or other important events. Investigators in Glasgow followed 78 such patients whose diagnosis had been confirmed by video-electroencephalographic analysis. Three (one of whom had previously had a glioma resected) developed a new type of attack, identified as complex partial seizures; they required retreatment with lower doses than before. Half of the remainder reported freedom from attacks for at least two months at one year follow-up, and only one patient reported an increase. Preceding comorbidity, such as medically unexplained symptoms, depression, and dependence on social security benefits, was common, but only 18% reported new symptoms after …

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