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Vitamin E, donepezil don't slow progression of mild cognitive impairment

BMJ 2005; 331 doi: https://doi.org/10.1136/bmj.331.7515.0-f (Published 01 September 2005) Cite this as: BMJ 2005;331:0-f

Question Does vitamin E or donepezil (Aricept) prevent progression from mild cognitive impairment to Alzheimer's disease?

Synopsis Mild cognitive impairment (MCI) is an intermediate stage between normal cognition and Alzheimer's disease, often characterised by deficits of memory. In this study, researchers identified 769 patients with mild cognitive impairment, defined as impaired memory on standardised tests, a mini mental state test score between 24 and 30, and age 55-90 years. These patients were randomly assigned to receive either …

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