Letters

Drug combinations and all cause mortality in heart disease: Authors' reply

BMJ 2005; 331 doi: https://doi.org/10.1136/bmj.331.7509.160 (Published 14 July 2005) Cite this as: BMJ 2005;331:160
  1. Julia Hippisley-Cox, professor of clinical epidemiology and general practice (julia.hippisley-cox@nottingham.ac.uk),
  2. Carol Coupland, senior lecturer in medical statistics
  1. Division of Primary Care, School of Community Health Sciences, Nottingham NG2 7RD
  2. Division of Primary Care, School of Community Health Sciences, Nottingham NG2 7RD

    EDITOR—There can be no substitute for a properly conducted randomised controlled trial in determining effectiveness of different treatments. All observational studies, however carefully designed and analysed, are subject to unmeasured confounding, as we point out in our paper. We think our study adds to the work on the Polypill by Wald and Law in providing more direct evidence on combinations of individual treatments as used in clinical practice in the …

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