Surveying the literature from animal experiments: Systematic review and meta-analysis are important contributions

BMJ 2005; 331 doi: https://doi.org/10.1136/bmj.331.7508.110-b (Published 07 July 2005) Cite this as: BMJ 2005;331:110
  1. Malcolm R Macleod, specialist registrar, neurology (malcolm@apoptosis.freeserve.co.uk),
  2. Shah Ebrahim, professor of epidemiology of ageing,
  3. Ian Roberts, professor
  1. Western General Hospital, Edinburgh EH4 2XU
  2. Department of Social Medicine, University of Bristol, Bristol BS8 2PR
  3. Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London WC1E 7HT

    EDITOR—We agree with Lemon and Dunnett that better methods of surveying the literature on animal experiments are needed,1 but we do not share their confidence in the utility of non-systematic reviews.

    In clinical trials, systematic review and meta-analysis have made important contributions to our understanding of sources of bias, and the quality of clinical trials has improved as a result. We …

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