Do selective serotonin reuptake inhibitors cause suicide?: Let's keep it in perspective

doi:10.1136/bmj.330.7500.1149-a

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Isaac Sakinofsky, professor emeritus of psychiatry and public health sciences (isaac.sakinofsky@utoronto.ca),
David L Streiner, director

University of Toronto, CAMH-Clarke Site, 250 College Street, Toronto, ON, Canada M5T 1R8
Kunin-Lunenfeld Applied Research Unit, Baycrest Centre for Geriatric Care, Toronto, ON, Canada M6A 2E1

EDITOR—The news media's preoccupation with whether antidepressants provoke suicidal behaviour has generated apprehension in the general public, and clinicians increasingly see patients resistant to taking selective serotonin reuptake inhibitors (SSRIs) even though they might benefit. The meta-analysis by Fergusson et al reported an excess of suicidal attempts with SSRIs v placebo and, initially, an alarming …