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Higher dose chemotherapy improves survival from breast cancer

BMJ 2005; 330 doi: https://doi.org/10.1136/bmj.330.7490.500-b (Published 03 March 2005) Cite this as: BMJ 2005;330:500
  1. Susan Mayor
  1. London

    Higher dose chemotherapy reduces overall risk of relapse after breast cancer by 22% compared with less aggressive regimens. Similar benefits were seen in older and younger women, results from a meta-analysis show (JAMA 2005;293:1073-81).

    The study retrospectively analysed data from four randomised clinical trials of treatments for lymph node positive breast cancer in 1975-99. Each trial compared more aggressive with less aggressive chemotherapy regimens, including a treatment arm using drug doses or schedules that were regarded as being high.

    A total of 6487 women with lymph node positive breast cancer were included, with 542 …

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