Higher dose chemotherapy improves survival from breast cancerBMJ 2005; 330 doi: https://doi.org/10.1136/bmj.330.7490.500-b (Published 03 March 2005) Cite this as: BMJ 2005;330:500
- Susan Mayor
Higher dose chemotherapy reduces overall risk of relapse after breast cancer by 22% compared with less aggressive regimens. Similar benefits were seen in older and younger women, results from a meta-analysis show (JAMA 2005;293:1073-81).
The study retrospectively analysed data from four randomised clinical trials of treatments for lymph node positive breast cancer in 1975-99. Each trial compared more aggressive with less aggressive chemotherapy regimens, including a treatment arm using drug doses or schedules that were regarded as being high.
A total of 6487 women with lymph node positive breast cancer were included, with 542 …