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THREAD trial may show way forward

Robert Peveler, professor of liaison psychiatry (rcp@soton.ac.uk),
Tony Kendrick, professor of primary medical care,
THREAD Study Group

University of Southampton, Royal South Hants Hospital, Southampton SO14 0YG
University of Southampton, Aldermoor Health Centre, Southampton SO16 5ST

EDITOR—Geddes and Cipriani comment that available randomised evidence does not provide reliable estimates of the costs and benefits of treatment with selective serotonin reuptake inhibitors (SSRIs) in patients with varying degrees of severity and laments the decline in non-commercial funding.1 Recent guidelines from the National Institute for National Excellence (NICE) also lack evidence.2 The NHS health technology assessment programme is funding a trial …