HRT is associated with increased risk of strokeBMJ 2005; 330 doi: https://doi.org/10.1136/bmj.330.7487.0 (Published 10 February 2005) Cite this as: BMJ 2005;330:0
Hormone replacement therapy (HRT) does not protect postmenopausal women from stroke, but rather increases the risk, particularly of ischaemic stroke. On page 342, Bath and Gray report the results of a meta-analysis of 28 randomised controlled trials with 39 769 participants. Hormone replacement therapy significantly increased the risk of total stroke, non-fatal stroke, stroke leading to death or disability, and ischaemic stroke and was associated with a trend to more fatal stroke. They found no evidence of the association with haemorrhagic stroke or transient ischaemic attack.