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Antibiotic halves number of AIDS related deaths in children in Zambian study

BMJ 2004; 329 doi: http://dx.doi.org/10.1136/bmj.329.7477.1258-b (Published 25 November 2004) Cite this as: BMJ 2004;329:1258
  1. Debashis Singh
  1. London

    All children with HIV in developing countries should be given prophylactic co-trimoxazole, a cheap and widely available antibiotic, a research paper from the Medical Research Council says (Lancet 2004;364:1865-71).

    The study found that a daily dose of the antibiotic resulted in a 43% lower mortality in children with HIV in Lusaka, Zambia, who were treated with the antibiotic than in a matched group of children taking a placebo, by preventing opportunistic infections irrespective of local antibiotic resistance. Co-trimoxazole also reduced admission rates to the University Teaching Hospital in Lusaka …

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