Clinical Review

Traditional herbal medicines for malaria

BMJ 2004; 329 doi: (Published 11 November 2004) Cite this as: BMJ 2004;329:1156
  1. Merlin L Willcox (merlinwillcox{at}, secretary1,
  2. Gerard Bodeker, senior lecturer in public health2
  1. 1 Research Initiative for Traditional Antimalarial Methods (RITAM), Buckingham MK18 7EW
  2. 2 Division of Medical Sciences, Medical Sciences Office, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU
  1. Correspondence to: M Willcox


    Traditional medicines have been used to treat malaria for thousands of years and are the source of the two main groups (artemisinin and quinine derivatives) of modern antimalarial drugs. With the problems of increasing levels of drug resistance and difficulties in poor areas of being able to afford and access effective antimalarial drugs, traditional medicines could be an important and sustainable source of treatment.

    The Research Initiative on Traditional Antimalarial Methods (RITAM) was founded in 1999 with the aim of furthering research on traditional medicines for malaria.1 The initiative now has in excess of 200 members from over 30 countries. It has conducted systematic literature reviews and prepared guidelines aiming to standardise and improve the quality of ethnobotanical, pharmacological, and clinical studies on herbal antimalarials and on plant based methods of insect repellence and vector control. We review some of this work and outline what can be learnt from the developing countries on the management and control of malaria.

    Sources and selection criteria

    We carried out searches of relevant articles published up to 2004 through Medline, Embase, CAB, Sociofile, and the central clinical trials database of the Cochrane Library, using the terms “traditional medicine” and “malaria”, “malaria-therapy”, “knowledge,-attitudes,-practice”, “self-medication”, and “drug-utilisation”. We also searched the references of identified articles and handsearched journals on ethnobotany, herbal medicines, and tropical medicine, such as the Journal of Ethnopharmacology, Fitoterapia, Transactions of the Royal Society of Tropical Medicine and Hygiene, Tropical Medicine, and International Health. Authors were contacted for unpublished papers.

    Summary points

    Over 1200 plant species from 160 families are used to treat malaria and fever

    On average, a fifth of patients use traditional herbal remedies for malaria in endemic countries

    Larger, more rigorous randomised controlled trials are needed with long term follow up

    So far only a few studies have reported on side effects from preparations

    In one trial, some patients stopped treatment due to minor side effects

    We sought evidence for how often herbal medicines are used to treat malaria, and what factors affect this; which plants are most commonly used; and the clinical safety and efficacy of preparations from these plants (see

    We entered each cited species into a database and assigned an IVmal (importance value for the treatment of malaria) according to how widely its use was reported. This system was first developed for use at a local level,2 with values ranging from 1 to 4. We have extended this system to apply at an international level by creating additional values from 5 to 8 (table 1).

    Table 1

    Number of plant species according to importance value for treatment of malaria (IVmal)

    View this table:

    Use of herbal antimalarials

    The proportion of patients using traditional herbal remedies for malaria varies widely. A meta-analysis carried out by us of 28 studies on treatment seeking behaviour showed that 307 of 315 458 respondents used such remedies. The overall percentage was 20%, but this value is misleading because the range varied widely from 0% to 75%. Many factors influence the use of traditional medicines to treat malaria (see box).3

    Plant species

    To date, 1277 plant species from 160 families used to treat malaria or fever have been listed on a database (figure). More studies are yet to be included in the database. Table 1 lists the number of species in each category of IVmal for 428 of the listed plants. Eight hundred and forty nine species were quoted only once in the studies consulted, therefore there is not enough information to generate a IVmal, but it must be 3 or less. Eleven species were used as antimalarials or antipyretics in all three tropical continents (table 2), and 47 species were similarly used in two continents. Most of the species (1213 plants) are not featured in the World Conservation Union's (IUCN) red list of threatened groups: of those that are, 5 were listed as “endangered,” 13 were listed as “vulnerable,” and 3 were listed as “near threatened.”

    Table 2

    Plant species used as antipyretics or antimalarials in three continents (importance value for treatment of malaria, 8)

    View this table:

    Embedded Image

    Leaf preparations of Kalanchoe pinnata are used to treat fever and malaria in Africa, Asia, and Latin America

    Clinical safety and efficacy of herbal preparations

    Eighteen case studies have reported on herbal antimalarials. Of cohort studies mentioning herbal treatments, 17 were for falciparum malaria, 12 for vivax malaria, and 5 for malaria of undefined species. Table 3 provides details of 10 controlled trials of herbal preparations for uncomplicated malaria.

    Table 3

    Trials of herbal medicines for uncomplicated malaria

    View this table:

    Often studies provided limited information on the methods used to prepare the remedies, making it difficult to replicate them. In some cases, this was deliberate, to protect intellectual property rights.4

    Few studies (3 case studies, 13 cohort studies, 4 controlled trials) provided data on side effects. It seems that in the other studies, patients were not questioned about adverse effects or new symptoms since starting treatment. None of the studies reported serious adverse effects. Only three of the cohort studies and three of the controlled trials reported effects on biochemical variables (most commonly liver function tests), and two studies monitored electrocardiograms. No cases of toxicity were reported. Minor side effects can, however, be important. For example, almost half of the patients taking the Ugandan herbal remedy “AM” experienced one or more minor side effects.4 These were sufficiently unpleasant in some cases to deter patients from continuing treatment (for example, diarrhoea, bitter taste). Some herbal antimalarials have a bitter taste, making it difficult to give them to children. Doses often need to be taken repeatedly, and the volume may be larger than with conventional drugs.5

    Six of the cohort studies on falciparum malaria reported 100% parasite clearance on days 4-7 after treatment, and a further three reported clearance rates above 90%. Follow up data beyond this time are available for only two of these nine studies, however, and only five of them studied more than 40 patients. One problem with cohort studies is that the trial population may be semi-immune to malaria and thus may clear parasites and resolve symptoms without effective treatment. High clearance rates may therefore not indicate efficacy. In highly endemic areas (as in much of sub-Saharan Africa), children aged over 5 years are considered to have a good immune response to malaria. In areas with high transmission of malaria, achieving complete parasite clearance for any length of time may not be realistic. In these circumstances, WHO recommends that adequate clinical response is a more useful measure of treatment efficacy. Such a response is defined as the absence of parasitaemia on day 14 or absence of fever (regardless of parasitaemia), without previously meeting the criteria for an early treatment failure.6

    Influences on use of herbal antimalarials

    • Study design

      Community compared with clinic (traditional or Western) setting

      Questions asked (open or closed, retrospective or prospective) and by whom (community member or healthcare staff)

    • Definition of “malaria” or “fever”

    • Factors involved in treatment seeking behaviours

      Perceived efficacy

      Availability of traditional and Western medicines


      Location: urban or rural

      Age: adult or child

    Some remedies may produce low rates of parasite clearance but higher rates of adequate clinical response. For example, in one study, parasitaemia declined to insignificant levels and patients were clinically cured after treatment with a decoction of Terraplis interretis.7 In another study, the Ugandan herbal remedy “AM” cleared parasites in only 8% of patients, but parasitaemia declined to lower levels, and 55% of patients had an adequate clinical response.4

    Not all of the 10 controlled trials were randomised or double blind (table 3). Four trials of the Ayurvedic remedy Ayush-64 to treat vivax malaria were reported to be double blind because both the herbal preparation and the comparator drug were provided in identical capsules.58 Patients randomised to receive either herbal decoctions or chloroquine tablets cannot be blinded, but laboratory technicians who count the parasites can be, and in one trial they were blinded.910 Blinding was not reported for the other trials. One early trial was placebo controlled,11 which would now be considered unethical.

    An aqueous root extract of Cryptolepis sanguinolenta shows promise in the treatment of falciparum malaria.12 Parasite clearance was only one day longer with this remedy than with chloroquine, and the clearance of fever was faster by 12 hours. A larger trial is needed to confirm these results, however, as the number of patients was small. In another trial comparing the treatment of falciparum malaria with quinine or with infusions of Artemisia annua, the infusions resulted in good parasite clearance at day 7.13 A high proportion of patients experienced a recrudescence, however, so that by day 28 only 37% of those treated with Artemisia annua were still free of parasites compared with 86% of patients treated with quinine. This emphasises the need for a follow up period of at least 28 days. Nevertheless, adequate clinical response, which is more important than parasite clearance in endemic areas,6 was not reported in this trial. In the trial of the herbal remedy “Malarial” (Suma-Kala), parasites were not cleared completely, but there was a good clinical response, which was sustained for the three weeks of follow up.9 10 In the trial of Cochlospermum tinctorium, patients were only followed for five days, and clinical outcomes were not used, so it is not possible to comment on long term efficacy.14

    Five of the 10 controlled trials only studied vivax malaria, four of which concerned the herbal remedy “Ayush-64.”5 8 Initial parasite clearance with Ayush-64 was good, but many patients relapsed by day 28. Another trial showed that oil based capsules of Artemisia annua cleared parasites and fever more rapidly than did chloroquine, and by day 30 only 8% of those given a course of capsules for six days showed recrudescence.15

    Future research

    Although traditional medicine is widely used to treat malaria, and is often more available and affordable than Western medicine, it is not without limitations. Firstly, there are few clinical data on safety and efficacy. Secondly, there is no consensus, even among traditional healers, on which plants, preparations, and dosages are the most effective. Thirdly, the concentration of active ingredients in a plant species varies considerably, depending on several factors.

    None the less, these limitations are all remediable, through research. The Research Initiative on Traditional Antimalarial Methods has written systematic reviews, some of which have been summarised here, and guidelines aiming to standardise and improve the quality of future research.3 These reviews and guidelines are far from complete. They should be seen as a springboard for further research rather than a definitive product.

    Additional educational resources

    Willcox ML, Bodeker G, Rasoanaivo P. Traditional medicinal plants and malaria. Boca Raton: CRC, 2004—book contains detailed systematic reviews and guidelines for further studies in malaria control

    The Research Initiative on Traditional Antimalarial Methods (—features a report of the inaugural meeting of RITAM

    World Health Organization Essential Drugs and Medicine Policy (—details WHO Traditional Medicine Strategy 2002-5

    The IVmal system is one way of prioritising plant species for future research. Plants that are used to treat malaria in several different areas are more likely to be effective.2 There are some drawbacks though. Plants may be prepared in many ways; so it might be more useful to discuss the IVmal of a particular remedy rather than of a plant species. The IVmal is also limited by the geographical distribution of plants and by the extent of ethnobotanical studies. In many areas no ethnobotanical study has been undertaken, and research in these areas is a priority. Traditional medicines are being forgotten with the death of healers who have no successors to their knowledge.

    Clinical observations on traditional remedies are feasible and useful. Some herbal remedies may be safe and effective for the treatment of malaria, as shown by the studies reviewed here. Nevertheless, better evidence from randomised clinical trials is needed before herbal remedies can be recommended on a large scale. As such trials are expensive and time consuming, it is important to prioritise remedies for clinical investigation according to existing data from sociological, ethnobotanical, pharmacological, and preliminary clinical observational studies. In remote settings with poor resources where modern antimalarials are not steadily available, research can provide an evidence base for traditional medicine, to inform local treatment choices.

    Preventing children's deaths is the key objective of any malaria control programme. Once a remedy has been shown to be safe and effective for uncomplicated malaria in adults, studies on mortality in children would be the necessary next step. It has already been shown that mortality can be reduced in the under 5s by training mothers to recognise malaria and to give early treatment.16

    The evidence summarised in this article, together with the guidelines proposed, should not only assist researchers already working in this specialty but also inspire other researchers and funding bodies to give serious consideration to the potential of traditional remedies for malaria.


    • Embedded Image A more detailed description of the methods is on

    • Contributors GB initiated this work, and MLW conducted the systematic reviews and wrote this article with his guidance. MLW is guarantor.

    • Funding The inaugural meeting of the Research Initiative on Traditional Antimalarial Methods (RITAM) was funded by Tropical Disease Research, the Rockefeller Foundation, and the Nuffield Foundation. The subsequent reviews were conducted on a voluntary basis.

    • Competing interests None declared.


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