Fillers POEM

Donepezil is ineffective in long term treatment of dementia

BMJ 2004; 329 doi: (Published 28 October 2004) Cite this as: BMJ 2004;329:0-g

Question Does donepezil provide clinically meaningful benefits in typical patients with Alzheimer's disease?

Synopsis This relatively complex randomised controlled trial (double blinded, with concealed allocation) had multiple phases designed to evaluate community dwelling elderly people with mild to moderate Alzheimer's disease (DSM-IV criteria). To start, 565 patients were randomised to receive 12 weeks of donepezil 5 mg daily or placebo. Following this initial treatment, 486 of these patients were re-randomised to receive 48 weeks of donepezil (5 or 10 mg daily) or placebo followed by …

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