Malaria vaccine shows encouraging results in childrenBMJ 2004; 329 doi: https://doi.org/10.1136/bmj.329.7472.938-b (Published 21 October 2004) Cite this as: BMJ 2004;329:938
- Susan Mayor
A malaria vaccine has shown encouraging results in children, according to a phase II study published last week (Lancet 2004;364:1411-20).
The study investigated the efficacy of a malaria vaccine, RTS,S/AS02A, directed against the Plasmodium falciparum sporozoite, the form of the malaria parasite that is injected into the human bloodstream by mosquitoes. The study was conducted on two cohorts of children aged 1-4 years living in Mozambique. Each cohort was divided into two groups, and the members of each group were randomly allocated to three doses of the malaria vaccine given intramuscularly or to control vaccines, including pneumococcal and hepatitis B vaccines.
The first cohort (1605 children) was followed up …