- James F Toole, director (jtoole@wfubmc.edu)
- Stroke Research Center, Wake Forest University Baptist Medical Center, Winston-Salem, NC 27157-1068 USA
The US Veterans' Administration study followed by the asymptomatic carotid artery stenosis study (ACAS) and now the asymptomatic carotid stenosis trial (ACST) have all affirmed that elective endarterectomy for patients carefully selected by neurologists and operated on by skilled surgeons can prevent stroke.1–2 w1 The results of ACST and ACAS are almost identical, with 5.4% absolute risk reduction for stroke in ACST compared with 5.9% for ACAS. The surgical advantage persists despite multimodal medical management with statins, platelet antiaggregants, and stringent control of risk factors. Moreover, nearly 20% of asymptomatic patients randomised to the medical management arm of ACST developed symtoms during the trial, often necessitating urgent surgery. These three randomised trials all show that if medical management has failed elective endarterectomy performed by skilled surgeons is a worthwhile additional …
Sign in
Personal subscribers, sign in here:
Article access
Article access for 1 day
Purchase this article for £20 $30 €32*
The PDF version can be downloaded as your personal record
CiteULike
Connotea
Del.icio.us
Digg
Facebook
Reddit
Technorati
Twitter
Stumbleupon
Rapid responses
Latest Responses
The decline in the breast cancer incidence is 1.2% and it is not significant.
Published 10 February 2012
'twas ever thus
Published 10 February 2012
The value of historic human remains
Published 10 February 2012
In Praise of British Literature
Published 10 February 2012
Is real shared decision making possible?
Published 10 February 2012
Most responses
Does anyone understand the government’s plan for the NHS? (17 responses)
Published 17 Jan 2012
Bad medicine: medical nutrition (15 responses)
Published 18 Jan 2012
Shared decision making: really putting patients at the centre of healthcare (7 responses)
Published 27 Jan 2012
Why legislation is necessary for my health reforms (7 responses)
Published 1 Feb 2012
Search for evidence goes on (5 responses)
Published 17 Jan 2012