Fillers POEM

Combinations of antiemetics are better for post-operative nausea and vomiting

BMJ 2004; 329 doi: https://doi.org/10.1136/bmj.329.7464.0-e (Published 26 August 2004) Cite this as: BMJ 2004;329:0-e

Question What is the best approach to preventing and treating postoperative nausea and vomiting?

Synopsis This is a well designed randomised controlled trial (single blinded) that examines all of the possible permutations of six approaches to reducing postoperative nausea and vomiting (PONV). The first three interventions had to do with the anaesthesia itself: propofol or a volatile anesthetic; nitrogen or nitrous oxide; and remifentanil or fentanyl. The other three interventions occurred postoperatively: 4 mg ondansetron or no ondansetron; 4 mg dexamethasone or no dexamethasone; and 1.25 mg droperidol or no droperidol. There are 64 different combinations of …

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