Treatment of hepatic encephalopathy: Authors' reply

BMJ 2004; 329 doi: https://doi.org/10.1136/bmj.329.7457.112-a (Published 08 July 2004) Cite this as: BMJ 2004;329:112
  1. Bodil Als-Nielsen, research fellow (Bodil.a@ctu.rh.dk),
  2. Lise L Gluud, research fellow,
  3. Christian Gluud, chief physician
  1. Cochrane Hepato-Biliary Group, Copenhagen Trial Unit, Centre for Clinical Intervention Research, Copenhagen University Hospital, Department 7102, H:S Rigshospitalet, DK-2100 Copenhagen, Denmark

    EDITOR—We do not agree that our Cochrane review clearly shows that lactulose is ineffective. The fact that we found no evidence of effect does not imply that there is evidence of no effect.1 It is difficult to prove that a treatment has no effect.1

    A survey of 989 abstracts of Cochrane reviews …

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