Fillers Q&A

Cocaine and amphetamine combined

BMJ 2004; 328 doi: http://dx.doi.org/10.1136/bmj.328.7452.1365 (Published 03 June 2004) Cite this as: BMJ 2004;328:1365

Question

What would happen if someone was to take a mixture of cocaine and amphetamine at the same time?

Elizabeth M Sobic, medical student

Birmingham

Answer

It depends on dose, route of administration, and history of drug misuse.

Both cocaine and the amphetamines developed originally for clinical use (including methamphetamine (or “ice”)) are psychomotor stimulants.1 They have broadly similar actions at the synaptic level (such as blocking reuptake of dopamine released from the meso-limbo-cortical dopamine terminals), the …

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