Low dose aspirin safely reduced thrombosis in polycythaemia vera

Question Is low dose aspirin safe and effective for the prevention of thrombotic complications in patients with polycythaemia vera?

Synopsis Polycythaemia vera is associated with increased blood viscosity, which in turn leads to thrombotic complications. A previous study with high dose aspirin (900 mg/day) was unsuccessful because of a high risk of gastrointestinal bleeding. In this randomised controlled (double blinded) study, 518 patients with polycythaemia, no contraindication to aspirin, and no other indication for antithrombotic therapy were randomised (allocation concealed) to aspirin …