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Fondaparinux is as effective and safe as unfractionated heparin for pulmonary embolism

BMJ 2004; 328 doi: http://dx.doi.org/10.1136/bmj.328.7439.0-f (Published 04 March 2004) Cite this as: BMJ 2004;328:0-f

Question Is fondaparinux as safe and effective as unfractionated heparin for treating pulmonary embolism?

Synopsis Fondaparinux (Arixtra) is an inhibitor of factor Xa. Although it's not a low molecular weight heparin, it's similar in that it's given by subcutaneous injection and does not require monitoring of anticoagulation. Alternatives to unfractionated heparin are widely used for treating deep vein thrombosis, but they are less widely used for pulmonary embolism because of concerns about efficacy. In the current randomised controlled trial (non-blinded), 2213 adults …

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