Treatment of unilateral visual impairment on preschool vision screening: Author's reply

doi:10.1136/bmj.328.7435.348-c

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Michael Clarke, university reader in ophthalmology (M.P.Clarke@ncl.ac.uk)

Claremont Wing, Royal Victoria Infirmary, Newcastle upon Tyne NE1 4LP

EDITOR—O'Brien seems to attach greater weight to a study of apparently declining acuity in a non-compliant group than to our observation in a randomised controlled study of no deterioration in our control group, who showed the same eventual result from deferred treatment. This simply illustrates again the pitfalls inherent in natural history studies, which are plagued by unmeasurable …