Timing of simvastatin treatment: Authors' reply

BMJ 2004; 328 doi: https://doi.org/10.1136/bmj.328.7432.168-a (Published 15 January 2004) Cite this as: BMJ 2004;328:168
  1. Alan Wallace,
  2. David Chinn (david.chinn@sunderland.ac.uk), senior research fellow,
  3. Greg Rubin, professor
  1. Grangewood Surgery, Houghton le Spring, Tyne and Wear DH4 4RB.
  2. Centre for Primary and Community Care, Benedict Building, University of Sunderland, Sunderland, Tyne and Wear SR2 7BW

    EDITOR—Young, Ewald, and Calvert et al raise an important design issue about the interval between giving simvastatin (evening or morning) and collecting blood samples (morning) for assessing cholesterol concentrations. Simvastatin not only lowers plasma cholesterol concentrations but markedly reduces their diurnal variation.1 Hence, bias arising from differences in the interval between drug administration and blood collection should …

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