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Cognitive behaviour therapy affects brain activity differently from antidepressants

BMJ 2004; 328 doi: https://doi.org/10.1136/bmj.328.7431.69-a (Published 09 January 2004) Cite this as: BMJ 2004;328:69
  1. Sue Mayor
  1. London

    Cognitive behaviour therapy triggers a different pattern of changes in brain activity than that triggered by the antidepressant paroxetine, according to a small pilot study that provides the first scan based evidence that the treatments work in different ways.

    The researchers scanned 17 previously untreated patients with unipolar depression before and after a 15-20 session course of outpatient cognitive behaviour therapy. The group's mean score on the 17 item Hamilton depression rating scale, which rates …

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