Insomnia: Principles and ManagementBMJ 2004; 328 doi: http://dx.doi.org/10.1136/bmj.328.7430.55-a (Published 01 January 2004) Cite this as: BMJ 2004;328:55
- Nava Zisapel, professor of biochemistry
- department of neurobiochemistry, the George S Wise Faculty of Life Sciences, Tel Aviv University, Israel
Sleep—a state marked by lessened consciousness, lessened movement of the skeletal muscles, and slowed-down metabolism—has an essential restorative function and an important role in memory consolidation. It is an orchestrated neurochemical process involving sleep promoting and arousal centres in the brain. Sleep propensity depends on two main factors: the amount of accumulated sleep deprivation and the circadian clock phase enhancing sleep at night.
Insomnia is a symptom, resulting from insufficient sleep or sleep of poor quality, with negative effects on subsequent daytime functioning. The prevalence of insomnia increases steeply during the fifth decade of …
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