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Scientists find gene linking inherited breast and ovarian cancer to non-inherited cases

BMJ 2003; 327 doi: https://doi.org/10.1136/bmj.327.7426.1247-a (Published 27 November 2003) Cite this as: BMJ 2003;327:1247
  1. Susan Mayor
  1. London

    A new gene for breast and ovarian cancer has been identified, which explains the link between hereditary and “sporadic” (non-inherited) forms of these cancers.

    It has been known for some time that mutations in the BRCA1 and BRCA2 genes are associated with inherited breast and ovarian cancer. However, only 5% of breast cancers are inherited and no role had been found for these genes in non-inherited cancers.

    Researchers have been hunting for the genes associated with sporadic breast cancers–95% of cases–ever since the BRCA genes were first identified, eight years ago.

    Research published this week has identified a new gene, EMSY, which …

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