Longevity and C282Y mutation for haemochromatosis: Authors' reply

BMJ 2003; 327 doi: https://doi.org/10.1136/bmj.327.7421.991 (Published 23 October 2003) Cite this as: BMJ 2003;327:991
  1. Hélène Coppin, research scientist,
  2. Marie-Paule Roth, research scientist (roth@cict.fr),
  3. Hélène Blanché, research scientist
  1. INSERM U563, CHU Purpan, 31059 Toulouse Cedex 3, France
  2. INSERM U563, CHU Purpan, 31059 Toulouse Cedex 3, France
  3. Centre d'Etude du Polymorphisme Humain, Fondation Jean Dausset, 75010 Paris, France

    EDITOR–Although our primary goal was to test the hypothesis that people who are heterozygous for the HFE C282Y mutation would be underrepresented in a centenarian population, the coincidental discovery of two people who were homozygous among the centenarians raised several comments.

    We agree with Li et al that the penetrance of a genotype depends …

    View Full Text

    Sign in

    Log in through your institution

    Free trial

    Register for a free trial to thebmj.com to receive unlimited access to all content on thebmj.com for 14 days.
    Sign up for a free trial