Letters

Longevity and C282Y mutation for haemochromatosis: Data do not support conclusion

BMJ 2003; 327 doi: http://dx.doi.org/10.1136/bmj.327.7421.990 (Published 23 October 2003) Cite this as: BMJ 2003;327:990
  1. Andy C Y Li ([email protected]), research fellow,
  2. Jonathan Powell, senior lecturer
  1. Gastrointestinal Laboratory, Rayne Institute, St Thomas's Hospital, London SE1 7EH

    EDITOR–Coppin et al say that the survival of people who were homozygous for the C282Y mutation among a cohort of French centenarians without treatment for haemochromatosis supports the view that the penetrance of this abnormal HFE gene in causing iron overload related morbidity is low.1 We are not clear that this conclusion can be reached with the data provided.

    Most authorities regard …

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