“Polypill” to fight cardiovascular disease: Interpretation of trial data is optimistic

BMJ 2003; 327 doi: https://doi.org/10.1136/bmj.327.7418.808-b (Published 02 October 2003) Cite this as: BMJ 2003;327:808
  1. Gerd Assmann (assmann@uni-muenster.de), professor of laboratory medicine,
  2. Paul Cullen, research physician,
  3. Helmut Schulte, statistician
  1. Institute of Arteriosclerosis Research, University of Münster, Domagkstrasse 3, D-48149 Münster, Germany

    EDITOR—Rarely has the demand for empirical evidence of treatment benefit been as necessary as in the prevention of cardiovascular disease. Wald and Law doubt this approach, saying that a “Polypill” containing six drugs would reduce events of ischaemic heart disease by 88% and stroke by 80% and might therefore be given with impunity to …

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