Letters Conundrum of the HOPE study

Authors' reply

BMJ 2003; 327 doi: https://doi.org/10.1136/bmj.327.7416.682 (Published 18 September 2003) Cite this as: BMJ 2003;327:682
  1. J Bosch, assistant clinical professor (jackie@ccc.mcmaster.ca),
  2. S Yusuf, professor of medicine
  1. McMaster University, 237 Barton Street East, Hamilton, ON, Canada L8L 2X2

    EDITOR–Taylor speculates that the reason that the HOPE (heart outcomes prevention evaluation) study did not show a significant relation between blood pressure and outcome was because ramipril was taken at bedtime.1

    We believe that this assertion is incorrect for several reasons.

    Firstly, the population studied in the paper by Svensson et al differed substantially from the overall HOPE population.2 This substudy focused on 38 patients who had peripheral arterial disease …

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