SARS: understanding the coronavirus

BMJ 2003; 327 doi: https://doi.org/10.1136/bmj.327.7415.620-b (Published 11 September 2003) Cite this as: BMJ 2003;327:620

Apoptosis may explain lymphopenia of SARS

  1. Roddy O'Donnell, associate lecturer, paediatrics (roddy.odonnell@addenbrookes.nhs.uk),
  2. Robert C Tasker, university lecturer, paediatrics,
  3. Michael F E Roe, clinical research fellow
  1. Clinical School, University of Cambridge, Cambridge CB2 2QQ

    EDITOR—In their review of the severe acute respiratory syndrome (SARS) Wong et al emphasise lymphopenia as a hallmark feature.1 Panesar suggested that glucocorticoids or stimulation of the hypothalamic-pituitary-adrenal axis leads to lymphocyte margination and that patients without lymphopenia may have adrenal insufficiency.2

    Apoptosis may also explain the lymphopenia of …

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