Helicobacter pylori in gastro-oesophageal reflux disease needs comparator

doi:10.1136/bmj.326.7404.1460

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Grigoris I Leontiadis (grleo@yahoo.com), senior clinical fellow in gastroenterology,
Savvas Kadis, consultant gastroenterologist,
Virender K Sharma, senior associate consultant,
Colin W Howden, professor of medicine

Queen Elizabeth Hospital, Gateshead, Tyne and Wear NE9 6SX
Division of Gastroenterology, Mayo Clinic, Scottsdale, Arizona, USA
Division of Gastroenterology, Northwestern University, Feinberg School of Medicine, Chicago, Illinois, USA

EDITOR—The systematic review by Raghunath et al was rigorous and well intentioned.1 However, their conclusion that the prevalence of Helicobacter pylori infection was significantly lower in patients with than without gastro-oesophageal reflux disease may be potentially misleading. The pooled control group in the meta-analysis was …