Methotrexate and bone marrow suppression: Drug errors may be implicated in death

BMJ 2003; 326 doi: https://doi.org/10.1136/bmj.326.7399.1145-b (Published 22 May 2003) Cite this as: BMJ 2003;326:1145
  1. Matthew L Grove, consultant rheumatologist (Matthew.Grove@northumbria-healthcare.nhs.uk)
  1. North Tyneside General Hospital, North Shields NE29 8NH

    EDITOR—Two points arise from the lesson of the week by Sosin and Handa on methotrexate toxicity.1

    Firstly, bone marrow toxicity with methotrexate is a late complication of treatment. Only one of the cases described (case 2) had been treated for less than 12 months, and the authors suspect he had been taking methotrexate daily rather than weekly as would have …

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