Fillers POEM

Harms outweigh benefits of COX 2 for many patients

BMJ 2003; 326 doi: (Published 15 March 2003) Cite this as: BMJ 2003;326:f

Question How safe are COX 2 inhibitors?

Synopsis This is an excellent (although non-systematic) review of the benefits and harms of COX 2 inhibitors. It is non-systematic because we aren't given details of the author's search strategy or inclusion criteria, and he only really discusses the two large COX 2 trials (VIGOR for rofecoxib and CLASS for celecoxib). Nevertheless, these two studies are the 800 pound gorillas in this area, and the author took advantage of …

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