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Digoxin levels should be kept to a minimum in men with heart failure

BMJ 2003; 326 doi: http://dx.doi.org/10.1136/bmj.326.7387.468/e (Published 01 March 2003) Cite this as: BMJ 2003;326:468
  1. Scott Gottlieb
  1. New York

    The heart drug digoxin seems to increase survival in men with heart failure but only when the blood level of the drug is kept to a minimum. With higher levels, the drug provides no benefit and may even be harmful (JAMA 2003;289:871-8).

    The new findings are based on a post hoc analysis of data from the Digitalis Investigation Group (DIG) trial, conducted from August 1991 to December 1995 and published in 1997. The DIG trial seemed to show that digoxin did not increase survival but did help to keep patients out of hospital …

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