MinervaBMJ 2003; 326 doi: https://doi.org/10.1136/bmj.326.7383.292 (Published 01 February 2003) Cite this as: BMJ 2003;326:292
In many countries colorectal cancers are second only to lung cancer as a cause of death from cancer. Prevention is by screening, reduction in exposure to chemical and other environmental agents, and chemoprevention by long term treatment with non-steroidal anti-inflammatory drugs. In studies of patients with arthritis results have shown that the risk of developing bowel cancer and mortality from the disease is lower among those taking such drugs (Cancer Investigation 2002;20:1002-11). The problem is the high frequency of side effects, and the search for safer alternatives continues.
Once colorectal cancer is diagnosed the outlook is still not very good, but in the past 20 years operative mortality has fallen substantially. A study from France of 4745 patients …
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