Evidence That Really Matters

Ice cream evoked headaches (ICE-H) study: randomised trial of accelerated versus cautious ice cream eating regimen

BMJ 2002; 325 doi: http://dx.doi.org/10.1136/bmj.325.7378.1445 (Published 21 December 2002) Cite this as: BMJ 2002;325:1445
  1. Maya Kaczorowski, grade 8 studenta,
  2. Janusz Kaczorowski, associate professor (kaczorow{at}mcmaster.ca)b
  1. a Dalewood Middle School, Hamilton, ON, Canada,
  2. b Department of Family Medicine, McMaster University, Hamilton, ON, Canada
  1. Correspondence to: J Kaczorowski

    Cold stimulus headache, also known as ice cream headache, is a common problem and is reported to occur in about a third of a randomly selected population.1 It was further suggested that the ice cream headache could be induced only in hot weather.2 A Medline search from 1966 to August 2002 with the MeSH terms and combination operators “ice cream,” “headache,” and “randomized controlled trial” to identify English language trials in this area produced no results.

    In order to fill this important knowledge gap, we compared the effect of two ice cream eating regimens on the incidence of ice cream induced headaches in a prospective randomised manner. The study was carried out during the winter to test whether this phenomenon was restricted to hot weather only.

    Participants, methods, and results

    All 145 students at Dalewood Middle School in Hamilton (Canada) in classes 63, 81, 82, 83, 84, and 85 were eligible to participate and were approached by the principal author after permission was received from the school's teachers. They were told the purpose of the study and the potential risks and benefits and were asked to provide verbal consent.

    The sample size calculation was performed assuming a 10% incidence of ice cream headache with cautious ice cream eating and that a 20% absolute increase in incidence between eating regimens would justify mum's nagging. To detect this level of difference with 80% power would require 71 participants in each arm of the trial.

    Participants were randomised via a concealed (face down) distribution of scrambled, stapled baseline and exit questionnaires marked with a red or green dot in the upper left corner. All participants were instructed to complete a baseline questionnaire recording age, sex, headache history, and lifetime prevalence of ice cream headache. Participants who received green dot questionnaires were given 100 ml of ice cream and were told to eat it in >30 seconds. They were further instructed to have about half their ice cream left after 30 seconds and then to continue at their own pace. Participants who received red dot questionnaires were given 100 ml of ice cream but were instructed to eat it in <5 seconds. The temperature of the ice cream was not formally regulated throughout the study. There were six eating sessions between December 2001 and January 2002 that included 21 to 28 participants, and each session compared both eating regimens.

    The primary outcome measure was the incidence and duration of ice cream headache assessed via self reported questionnaires completed 5-10 minutes after eating the ice cream. All statistical tests were conducted on an intention to treat basis and were two tailed (P<0.05).

    All 145 students from six classes who were approached provided verbal consent. There were no refusals and no loss to follow up. The table shows the baseline characteristics of the two groups.

    Characteristics of the 145 participants at enrolment in the ICE-H trial. Values are numbers (percentages) of participants unless stated otherwise

    View this table:

    Twenty (27%) of 73 students in the accelerated eating group reported ice cream headache compared with 9 (13%) of 72 students in the cautious eating group (relative risk 2.2 (95% confidence interval 1.03 to 4.94), number needed to harm 6.71 (3.79 to 200.48)). Of the 29 headaches reported, 17 (59%) lasted for less than 10 seconds. The lifetime prevalence of ice cream headache among the participants was 115/145 (79% (73% to 86%)).

    Comment

    The main weaknesses of our study were lack of blinding and the use of self reporting to ascertain the main outcome measure. Nevertheless, these findings confirm that cold stimulation of the palate induced by gobbling up ice cream more than doubles the likelihood of developing ice cream headache among middle school students. In contrast to previous studies, our results suggest that ice cream headache can be induced in cold weather even in subjects who eat their ice cream at a slow pace. The lifetime prevalence of ice cream headache was also considerably higher than what was previously reported.

    Acknowledgments

    We thank Ms A Charters, Mr P Sallewsky, and Ms N Diacon, who are teachers at Dalewood Middle School, as well as the students who participated in the study (classes 63, 81, 82, 83, 84, and 85). We also thank Isabelle Cottenceau, mother and wife respectively, of the investigators. Presented at the 2002 Bay Area Science and Engineering Fair (BASEF), April 3-6, 2002, Mohawk College, Hamilton, ON, Canada

    Footnotes

    • Funding This work was supported by an unrestricted grant from mum and dad.

    • Competing interests None declared.

    References