Thalidomide is not a human mutagen

BMJ 2002; 325 doi: https://doi.org/10.1136/bmj.325.7374.1245/a (Published 23 November 2002) Cite this as: BMJ 2002;325:1245
  1. J Ashby, senior research fellow (John.Ashby@Syngenta.com),
  2. H Tinwell, researcher
  1. Syngenta Central Toxicology Laboratory, Alderley Park, Macclesfield, Cheshire SK10 4TJ

    EDITOR—In 1994 McBride reported two cases of a malformed child born to fathers with thalidomide embryopathy.1 In case 1 the child had two unaffected brothers, and in case 2 the child had an unaffected older sibling. McBride suggested that thalidomide might be (the first) human germ cell mutagen. This contention was countered by several respondents, …

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