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Raised homocysteine levels not as risky as once thought

BMJ 2002; 325 doi: https://doi.org/10.1136/bmj.325.7371.989 (Published 02 November 2002) Cite this as: BMJ 2002;325:989
  1. Deborah Josefson
  1. Nebraska

    Two new meta-analyses confirm that a raised level of blood homocysteine is a risk factor for ischaemic heart disease but find that the risk is lower than previously thought (JAMA 2002;288:2015-22, 2023-31).

    The studies imply that to measure homocysteine levels routinely, in the way that cholesterol is now measured, may not be indicated.

    The first of the two meta-analyses, the homocysteine studies collaboration, was conducted by Dr Robert Clarke and colleagues of the Radcliffe Infirmary in Oxford. The researchers searched Medline for articles on homocysteine and ischaemic heart disease or stroke risk …

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