Message about hormone replacement therapy is unclear

BMJ 2002; 325 doi: https://doi.org/10.1136/bmj.325.7371.1036 (Published 02 November 2002) Cite this as: BMJ 2002;325:1036
  1. J Michael Dixon (jmd@wght.demon.co.uk), consultant surgeon
  1. Academic Office, Edinburgh Breast Unit, Western General Hospital, Edinburgh EH4 2XU

    EDITOR—Two contrasting leading articles followed publication of the randomised trial of the women's health initiative study of hormone replacement therapy. 1 2

    Stevenson and Whitehead in the BMJ said that the increased risk of breast cancer in the study was small, but they did not mention that during the study 42% of women taking active drug and 38% receiving placebo stopped the assigned treatment.1

    In contrast, Fletcher and Colditz reported in JAMA that the intention to treat analysis may have underestimated the …

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