MiddlesexBMJ 2002; 325 doi: https://doi.org/10.1136/bmj.325.7370.975 (Published 26 October 2002) Cite this as: BMJ 2002;325:975
- John Quin, consultant physician. (John.Quin@bsuh.nhs.uk)
- Royal Sussex County Hospital, Brighton
Bloomsbury, £16.99, pp 529
Cal Stephanides is a 41 year old Greek-American cultural attaché working in Berlin. In this brilliant novel he looks back on his life as man and … girl. Born Calliope, he has 5α-reductase deficiency. This autosomal recessive disorder is characterised by impaired conversion of testosterone to dihydrotestosterone in androgen-dependent target cells. Thus the inspired Jeffrey Eugenides acknowledges his debt to Imperato-McGinley et al's paper in the Journal of Clinical Endocrinology and Metabolism(1992;75:1022-6).
Most patients are raised as females from birth but …