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Review warns that risks of long term HRT outweigh benefits

BMJ 2002; 325 doi: https://doi.org/10.1136/bmj.325.7366.673 (Published 28 September 2002) Cite this as: BMJ 2002;325:673
  1. Susan Mayor
  1. London

    The overall increased risk of serious adverse effects—including breast cancer, stroke, and pulmonary embolism—with long term hormone replacement therapy (HRT) outweighs the potential benefits in disease prevention, warns a review of major trials published last week.

    Researchers at the Cancer Research UK's epidemiology unit in Oxford were asked by the Lancet to review all trials of long term HRT after the early termination of one part of the women's health initiative trial showed increased risk of cardiovascular events (JAMA 2002;288:321-33)

    They analysed four randomised …

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