Gabapentin induced cholestasis

The treatment of painful diabetic peripheral neuropathy is troublesome and limited by the range of effective treatments available. Optimal control of diabetes is important, and simple analgesics such as aspirin and paracetamol may be beneficial. Further relief of symptoms may be achieved with tricyclic antidepressants and anticonvulsants.1 2 Unfortunately, despite these treatments many patients still have symptoms and the search for more effective therapy continues. Preliminary studies have shown that the anticonvulsant gabapentin is beneficial in the management of this condition, but this remains an unlicensed indication. We report a case of serious hepatotoxicity associated with gabapentin. 3 4

During a routine visit to a …