Depo-Provera contraceptive may increase risk of cardiovascular diseaseBMJ 2002; 325 doi: https://doi.org/10.1136/bmj.325.7363.513 (Published 07 September 2002) Cite this as: BMJ 2002;325:513
- Xavier Bosch
The long acting contraceptive Depo-Provera (depot medroxyprogesterone acetate, DMPA) may increase the risk of heart disease in women taking the drug for more than a year, new research has suggested.
The study, due to be published on 17 September in Circulation, the journal of the American Heart Association, and already available on line (www.circ.ahajournals.org/), shows that the contraceptive can impair arterial responsiveness to increased blood flow as a result of endothelial cell abnormality.
Lead author Professor Dudley Pennell of the Royal Brompton Hospital, London, …