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Researchers identify gene associated with airways remodelling in asthma

BMJ 2002; 325 doi: (Published 20 July 2002) Cite this as: BMJ 2002;325:123
  1. Susan Mayor
  1. London

    A joint US and UK consortium of researchers has identified a gene associated with airways remodelling in asthma, which offers a potential new target for developing drugs that can prevent changes in lung tissue that result in hyper-responsiveness.

    The researchers performed a genome-wide scan on 460 white families with “sib-pairs” (children having the same biological parents) diagnosed with asthma and being treated for the condition. They identified a locus on chromosome 20p13 that was linked to asthma (log10 of the likelihood ratio 2.94) and bronchial hyper-responsiveness (3.93).

    The gene—ADAM33 (a disintegrin and …

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