Papers
Drug points
Interaction between warfarin and topical miconazole cream
BMJ 2002; 325 doi: https://doi.org/10.1136/bmj.325.7355.77 (Published 13 July 2002) Cite this as: BMJ 2002;325:77
- A Devaraj,
- J P O'Beirne,
- R Veasey,
- A A Dunk
- Eastbourne District General Hospital, Eastbourne BN21 2UD
Miconazole is a broad spectrum antifungal agent. When co-administered with warfarin it may increase the anticoagulant effect of the warfarin by inhibiting hepatic microsomal cytochrome P-450 enzymes.1 Trace amounts of miconazole have been detected systemically after topical administration.2 An interaction of warfarin with miconazole oral gel and pessary formulations has also been reported.3–5 We report the loss …