- Alastair J Thomson (a.j.thomson@ed.ac.uk), research fellow,
- David J Webb (d.j.webb@ed.ac.uk), Christison professor of therapeutics and clinical pharmacology,
- Simon R J Maxwell (s.maxwell@ed.ac.uk), senior lecturer,
- Ian S Grant (i.s.grant@ed.ac.uk), consultant anaesthetist
- Clinical Pharmacology Unit, Department of Medical Sciences, Western General Hospital, University of Edinburgh, Edinburgh EH4 2XU
- Intensive Care Unit, Western General Hospital
The potential dangers of hyperoxia need to be recognised
Oxygen is cheap, widely available, and used in a range of settings and conditions to relieve or prevent tissue hypoxia. Since its discovery by Scheele and Priestley in the 1770s, it has remained one of the most effective therapeutic agents available. However, as a result of poor prescribing and monitoring, inappropriate doses are often given.1
Oxygen is most commonly delivered by devices with variable performance such as face masks and nasal cannulae. These can produce unexpectedly high concentrations of inspired oxygen, particularly when ventilation is depressed.2 In addition, masks that incorporate a reservoir bag are often used in emergencies, following the widespread adoption of advanced trauma life support style (or ATLS) guidelines. These appliances can produce systemic hyperoxia that is generally assumed to be harmless. However, emerging evidence suggests that for some patients with acute medical conditions, hyperoxia may be harmful.
Oxygen therapy is often …
Sign in
Article access
Article access for 1 day
Purchase this article for £20 $30 €32*
The PDF version can be downloaded as your personal record







CiteULike
Connotea
Del.icio.us
Digg
Facebook
Mendeley
Reddit
Technorati
Twitter
Stumbleupon
Rapid responses
Latest Responses
Re: Ventilator associated pneumonia
Published 30 May 2012
Re: Restless legs syndrome
Published 30 May 2012
Author's reply
Published 30 May 2012
Re: Full access to trial data holds many benefits and a few pitfalls, conference hears
Published 30 May 2012
Restless Legs Syndrome: Fact or Fiction
Published 30 May 2012
Most responses
Venous thrombosis in users of non-oral hormonal contraception: follow-up study, Denmark 2001-10 (12 responses)
Published 10 May 2012 - 23:32
The psychiatric oligarchs who medicalise normality (9 responses)
Published 2 May 2012 - 15:42
Are doctors justified in taking industrial action in defence of their pensions? No (8 responses)
Published 8 May 2012 - 12:21
Are doctors justified in taking industrial action in defence of their pensions? Yes (8 responses)
Published 8 May 2012 - 12:21
The hardest thing: admitting error (7 responses)
Published 2 May 2012 - 12:27