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Ovary removal can reduce risk of breast and ovarian cancer in women with gene mutations

BMJ 2002; 324 doi: https://doi.org/10.1136/bmj.324.7349.1295 (Published 01 June 2002) Cite this as: BMJ 2002;324:1295
  1. Scott Gottlieb
  1. New York

    Women who have the gene mutations BRCA1 or BRCA2 can reduce their likelihood of developing ovarian cancer and breast cancer by having prophylactic surgery to remove both ovaries, according to two new studies in the New England Journal of Medicine.

    However, because removing both ovaries substantially lowers the production of hormones, the researchers said there is some concern that hormone replacement therapy—which is required after the surgery—could raise the risk of cancer by restoring some of these hormones.

    Previous studies showed that women who carry the BRCA1 or BRCA2 …

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