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Study helps explain relation between heart disease and insulin resistance

BMJ 2002; 324 doi: (Published 30 March 2002) Cite this as: BMJ 2002;324:756
  1. Scott Gottlieb
  1. New York

    High blood concentrations of a naturally occurring compound involved in blood vessel function may help explain why patients with insulin resistance have a high risk of developing heart disease, a study shows.

    The study's findings also indicate that drugs that improve insulin sensitivity may reduce levels of the compound, asymmetric dimethylarginine (ADMA), and ultimately reduce a person's risk of developing heart disease (JAMA 2002;287:1420-6, 1451-2).

    Increased cardiovascular risk in diabetes is long believed to be related to dysfuntion of the endothelium in intact blood vessels. The …

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